Oral route(Solution) Serious, life-threatening, and fatal events from use of tamoxifen include uterine malignancies, stroke, and pulmonary embolism. Discuss risks and benefits of tamoxifen with women at high risk for breast cancer and women with ductal carcinoma in situ (DCIS) when considering tamoxifen use to reduce the risk of developing breast cancer. For most patients already diagnosed with breast cancer, the benefits of tamoxifen outweigh its risks . Oral route(Tablet) Serious and life-threatening uterine malignancies, stroke, and pulmonary embolism have been associated with tamoxifen use in the risk reduction setting (women with Ductal Carcinoma in Situ (DCIS) and women at high risk for breast cancer). Health care providers should discuss the potential benefits versus the potential risks of these serious events with women at high risk of breast cancer and women with DCIS considering tamoxifen to reduce their risk of developing breast cancer. The benefits of tamoxifen outweigh its risks in women already diagnosed with breast cancer . Therapeutic Class: Antiestrogen Tamoxifen is used to treat certain types of breast cancer (eg, estrogen receptor-positive breast cancer that has spread to other parts of the body [metastatic], early stage estrogen receptor-positive breast cancer after surgery and radiation treatment). It is also used to reduce the risk of invasive breast cancer in adult women with ductal carcinoma in situ (DCIS) after breast surgery and radiation treatment. Patients who take a commonly prescribed breast cancer drug, Tamoxifen (learn more about Tamoxifen here) are at an increased risk of developing blood clots. Researchers have discovered that this risk is much greater (500% higher) in some patients with a specific genetic mutation, called “Factor 5 Leiden” or FVL mutation. In my opinion, any patient who is on Tamoxifen and who is already at a high risk of blood clots (see the list of risk factors, below) should be offered this test. If you carry this mutation, you may be offered alternative medications (i.e. aromatase inhibitors) with no increased risk of blood clots. Ciprofloxacin xr Xanax diarrhea High blood pressure is found among people who take Tamoxifen citrate, especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years, also take medication Zometa, and have Osteoporosis. Apr 19, 2017. My blood pressue has always been really low. around 105/65. I was on Tamoxifen for 3 years and oddly enough, my blood pressure was. Tamoxifen can cause abnormalities of liver tests, reduced white blood cells, red blood cells, and platelets. Reduced platelets can lead to bleeding. Patients. Adjuvant treatment with the estrogen receptor modulator tamoxifen is a well established long-term therapy in breast cancer. This study investigated the effect of tamoxifen on blood pressure (BP) and on factors by which it might be influenced.12 months adjuvant tamoxifen therapy were randomized to withdraw or continue tamoxifen for 6 weeks and then to crossover to the alternative regimen for a second 6-week period. Measurements of clinic and ambulatory BP, plasma renin activity (PRA), and fractional sodium excretion (FETwenty-three women completed the study (mean age 60.6 ± 8.3 years). There was no effect of tamoxifen on clinic BP (mean difference between withdrawal and continuation for systolic BP, 0.4 ± 8.4 mm Hg, 95% confidence interval [CI] −4.0 to 3.2, and diastolic 0.6 ± 4.7, 95%CI −1.4 to 2.7) or 24-hour ambulatory BP (systolic 0.7 ± 7.4 mm Hg, 95%CI −2.6 to 3.9; diastolic BP, 1.9 ± 5.5, 95% CI −0.5 to 4.2). Furthermore, no effect of tamoxifen on PRA (mean difference between withdrawal and continuation 0.03 ± 0.5 ng/m L/h, 95% CI −0.3 to 0.2) or FE Hypertension is the strongest modifiable risk factor for stroke and one of the strongest for coronary heart disease. Prospective epidemiologic data have shown that a 5 mm Hg increase in the levels of diastolic blood pressure (BP) or 10 mm Hg in systolic BP for 5 years is associated with a 40% increase in the risk for stroke and 25% for coronary heart disease. Selective estrogen receptor modulators have been shown to act like estrogens in some target tissues but to antagonize their effects in others. Tamoxifen may cause cancer of the uterus (womb), strokes, and blood clots in the lungs. Tell your doctor if you have ever had a blood clot in the lungs or legs, a stroke, or a heart attack. Also tell your doctor if you smoke, if you have high blood pressure or diabetes, if your ability to move around during your waking hours is limited, or if you are taking anticoagulants ('blood thinners') such as warfarin (Coumadin). If you experience any of the following symptoms during or after your treatment, call your doctor immediately: abnormal vaginal bleeding; irregular menstrual periods; changes in vaginal discharge, especially if the discharge becomes bloody, brown, or rusty; pain or pressure in the pelvis (the stomach area below the belly button); leg swelling or tenderness; chest pain; shortness of breath; coughing up blood; sudden weakness, tingling, or numbness in your face, arm, or leg, especially on one side of your body; sudden confusion; difficulty speaking or understanding; sudden difficulty seeing in one or both eyes; sudden difficulty walking; dizziness; loss of balance or coordination; or sudden severe headache. You will need to have gynecological examinations (examinations of the female organs) regularly to find early signs of cancer of the uterus. If you are thinking about taking tamoxifen to reduce the chance that you will develop breast cancer, you should talk to your doctor about the risks and benefits of this treatment. You and your doctor will decide whether the possible benefit of tamoxifen treatment is worth the risks of taking the medication. If you need to take tamoxifen to treat breast cancer, the benefits of tamoxifen outweigh the risks. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with tamoxifen and each time you refill your prescription. Tamoxifen blood pressure Does tamoxifen cause high blood pressure? - Breast Cancer Care Forum., Does tamoxifen cause high blood pressure? - Breast Cancer Care. Fluconazole effects Being a woman; Getting older; Having blood relatives who had. If you smoke, are obese, or have or are being treated for high blood pressure or. of pre-cancer should not take tamoxifen to help lower breast cancer risk. Deciding Whether to Use Medicine to Reduce Breast Cancer Risk. Tamoxifen, Nolvadex Side Effects Weight Gain, Dosage & Dangers. Tamoxifen CITRATE - WebMD. A previous NIH study showed that breast cancer patients who took tamoxifen for. About 30 percent of people who have hypertension, or high blood pressure. In addition to its actions on the breast, tamoxifen produces. Heart rate values were derived from the blood pressure recordings and processed. Sep 13, 2012. Tamoxifen can increase your risk of developing blood clots, however that risk goes up 500% with a. Keep blood pressure under control.